With antibiotic-resistance spreading at a dire rate, novel treatments are desperately needed to manage the 3 million yearly infections in the U.S. alone. And while novel is usually synonymous with “new,” scientists at the University of Minnesota are searching in the opposite direction—they’re looking for solutions in fossils of the long-dead.
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What do you do after you help develop a vaccine that plays a role in halting the global pandemic that’s been plaguing the world for more than a year? If you’re the research team behind the Oxford/AstraZenca COVID-19 vaccine, you gear up to do it all over again.
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The compound targets a molecular pathway found in bacteria but not humans and could lead to new treatments for gonorrhea and infections from other bacteria, such as tuberculosis and MRSA.
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Researchers have solved a long-standing mystery of how living organisms distinguish RNA and DNA building blocks during gene expression paving the way for the design of new antiviral drugs.
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Home delivery of HIV medicines in South Africa significantly increased viral suppression compared to those who received clinical care, according to a new study.
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How has your job description changed over the years? Thirty years ago, odds are the responsibilities of someone in your role looked a lot different than yours do today. Sridhar Iyengar thinks the role of laboratory manager is one of those job positions with shifting modern responsibilities.
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Using the ZMAC cell line resulted in successful isolation of viruses 57.6% of the time, while the MARC-145 cell line was successful 26.3% of the time, according to the findings.
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Researchers have identified a critical mechanism that allows deadly bacteria to gain resistance to antibiotics. The findings offer a potential new drug target.
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Two mRNA vaccines not only changed the course of the global pandemic, but general vaccine R&D as well. Not three months later, however, the vaccine industry may be in for yet another revolution as researchers just filed a patent for a self-replicating RNA (saRNA) vaccine that can prevent malaria.
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Scientists have developed a greatly simplified method to make fluoroketones, precursors for drug design and manufacture that typically require a silver catalyst.
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Researchers have developed a hydrogel that, when injected into mice with melanoma, slowly released RNA nanovaccines that shrank tumors and kept them from metastasizing.
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Three decades-old antibiotics administered together can block a type of pain triggered by nerve damage in an animal model.
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The new technique may reduce drug side effects, and in the long term, ion pumps may help patients with symptoms of neurological diseases for which effective treatments are not available.
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Prescription drug prices in the U.S. are significantly higher than in other nations. The gap between prices in the U.S. and other countries is even larger for brand-named drugs, with U.S. prices averaging 3.44 times those in comparison nations.
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The leap in efficiency means patients with schizophrenia, bipolar disorder and other conditions could see their doses of powerful antipsychotic medications cut by as much as three quarters, which is expected to spare them from sometimes-debilitating side effects.
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