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The new FlowCam Nano from Fluid Imaging Technologies enables biopharmaceutical scientists to assess the colloidal stability of drug formulations to determine their resistance to aggregation over time. Ideal for testing therapeutic protein formulations, lyophilized biologics, and all injectable drugs, the instrument is the first imaging flow microscope that automatically detects, images and characterizes both micron- and submicron-sized particles in a fluid sample from 300 nm to 10 ┬Ám at the same time, allowing the aggregation or degradation of protein particles and additives to be tracked from manufacturing, storage, and transport through drug delivery. By understanding how the colloidal stability of different formulations compare, manufacturers are better able to balance efficacy, safety and shelf life to find the ideal formulation that remains stable throughout the process.

By providing high resolutions images for opaque, transparent and translucent sub-visible particles and corresponding measurement data using more than 40 different basic and advanced, morphological parameters, the microscope led the researchers to conclude the new instrumentation effectively assesses the colloidal stability of drug product formulations.
 

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