Credit: Research Institute of the Hospital del Mar.
The ICOD (Improving Condition in Down syndrome) project, a pioneering study in addressing the cognitive difficulties associated with Down syndrome, has demonstrated the safety of treatment with the molecule AEF0217, developed by the French biotech Aelis Farma, as well as its effectiveness in improving cognitive function. The study was led by the Research Institute of the Hospital del Mar.
This phase of the trial (phase 1/2 of the project) has been carried out with 29 people with Down syndrome between 18 and 35 years old with mild or moderate disability. The objective was to test the safety of the administration of the treatment as well as to explore the potential to improve the cognition and daily functionality of the participants. In a previous phase, its safety in people without this syndrome was already validated.
To carry out the study, the volunteers were given the molecule AEF0217, developed by Aelis Farma, or a placebo for 28 days. The results show both the safety of the treatment and the improvement in cognitive functions in people who received it compared to those who received placebo.
Measured with reference scales, it has been found that AEF0217 significantly improved behavioral skills in the areas of communication, daily living skills and social interactions. These improvements were also associated with a consistent trend toward greater cognitive flexibility, which is the ability to adapt to new situations or changes.
In addition, studies with electroencephalography, which look at spontaneous brain electrical functioning, show statistically significant changes in brain function after AEF0217 treatment, indicating that people with Down syndrome needed less effort to complete a work memory tasks. These results reinforce the idea that the treatment acts effectively at the brain, cognitive and functioning levels, providing initial promising concordant data on its beneficial potential.
"The effectiveness data are particularly striking, addressing crucial domains of adaptation such as expression and writing skills, as well as daily living skills and social interactions. These effects, obtained after only four weeks of treatment, are the first in the field of Down syndrome and represent an important step forward towards the development of a treatment that could significantly improve the autonomy and adaptation of these people," said Rafael de la Torre, who coordinates the ICOD project and conducted the clinical studies at the Hospital del Mar Research Intitute.
A new therapeutic approach
The molecule developed by Aelis Farma is based on the fact that people with Down syndrome have hyperactivity of the cannabinoid receptor CB1, according to several studies, which indicate that its modulation with specific inhibitors drastically improves cognitive performance in animal models. Treatment with AEF0217, the first drug in a new pharmacological class, CB1 Receptor Signaling Specific Inhibitors (CB1-SSi), mimics a natural defense mechanism of the brain to counteract the hyperactivity of this receptor. At the same time, the function of the APOE4 genotype—linked to endocannabinoid physiology and the main genetic risk factor for Alzheimer's—is also studied.
The team of Diego Real de Asua from the Hospital de la Princesa in Madrid also participated in the work. To carry it out, the collaboration of the participants, their families and family associations has been necessary, who have supported the project and have helped to complete this pioneering clinical trial.
The results obtained reinforce the continuity of the project and allow the team to move toward the next stage: an international multicenter phase 2 study that will begin in the middle of next year. This trial will focus on determining the appropriate dosage of the treatment to maximize its benefits. The objective will be to deepen the improvement of both functionality in daily life and specific cognitive functions in people with Down syndrome.
Republished courtesy of Research Institute of the Hospital del Mar.