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The Lead

Large-scale Test of Ebola Vaccine Begins

March 5, 2015 3:00 pm | by Associated Press, Maria Cheng | News | Comments

The World Health Organization will start large-scale testing of an experimental Ebola vaccine in Guinea on Saturday to see how effective it might be in preventing future outbreaks of the deadly virus.

Tree Leaf Molecule Helps Female Mice Fight Weight Gain

March 5, 2015 3:00 pm | by Cell Press | News | Comments

A study found that female mice treated with a molecule found in tree leaves could indulge in...

Busted: Vitamin D Deficiency Doesn't Cause Depression

March 2, 2015 3:00 pm | by ScienceNetwork WA | News | Comments

Researchers have long thought that low vitamin D could cause depression. However, new research...

Printing Offers New Drug Delivery Method

March 2, 2015 7:00 am | by Society of Interventional Radiology | News | Comments

Researchers and engineers collaborated to print catheters, stents and filaments that were...

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Commercialization Boot Camp for Scientists

March 2, 2015 7:00 am | by Michelle Taylor. Editor-in-Chief | Articles | Comments

In the last three years, the NSF has taught more than 700 teams of scientists how to commercialize their technology using serial entrepreneur Steve Blank’s “Lean Startup” method. Sharing a common interest to promote societal benefits, NSF teamed with the NIH to pioneer the same program to support biomedical innovation and translation.  

Immune ‘Hotspots’ Improve Breast Cancer Outcome

February 27, 2015 3:00 pm | by The Institute of Cancer Research | News | Comments

Scientists have developed a new test that can predict the survival chances of women with breast cancer by analyzing images of “hotspots” where there has been a fierce immune reaction to a tumor. Researchers used statistical software previously used in criminology studies of crime hotspots to track the extent to which the immune system was homing in and attacking breast cancer cells.

Cancer Drug Tested in Dogs Moves on to Humans

February 27, 2015 3:00 pm | by Univ. of Illinois | News | Comments

A new drug that prompts cancer cells to self-destruct while sparing healthy cells is now entering phase I clinical trials in humans. The drug, called PAC-1, first showed promise in the treatment of pet dogs with spontaneously occurring cancers, and is still in clinical trials in dogs with osteosarcoma.

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Asian Herb May Treat Ebola

February 27, 2015 7:00 am | by Texas Biomedical Research Institute | News | Comments

A team of scientists has announced that a small molecule called Tetrandrine, derived from an Asian herb, has shown to be a potent small molecule inhibiting infection of human white blood cells in vitro or petri dish experiments and prevented Ebola virus disease in mice.

One Million Men Used to Study Effects of Blocking Inflammation

February 26, 2015 3:00 pm | by Univ. of Cambridge | News | Comments

Inflammation— the body’s response to damaging stimuli— may have a protective effect against cardiovascular disease, according to a study. The finding is one of the outcomes of research using a powerful new genetic tool— containing data from over a million individuals— that mimics the behavior of certain anti-inflammatory drugs.

Natural Antifreeze in Ticks Fights Frostbite in Mice

February 26, 2015 7:00 am | by Yale Univ. | News | Comments

A protein that protects ticks from freezing temperatures also prevents frostbite when introduced in mice, a study has found. The research is the first to demonstrate the protein's ability to boost frostbite resistance in an adult mammal.

HIV Drug May Fight Strep, Flesh-eating Bacteria

February 25, 2015 3:00 pm | by ACS | News | Comments

With antibiotic resistance on the rise, scientists are looking for innovative ways to combat bacterial infections. The pathogen that causes conditions from strep throat to flesh-eating disease is among them, but scientists have now found a tool that could help them fight it: a drug approved to treat HIV.

Mussel Supplement Aids Damaged Muscles

February 25, 2015 7:00 am | by Indiana Univ. | News | Comments

There may be a greater connection between mussels and muscles than previously thought. The study has found that taking a pre-exercise supplement of the omega-3 PCSO-524, a marine oil lipid derived from the New Zealand green-lipped mussel, has significant positive effects on post-exercise muscle damage.

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Mentally Ill Patients Less Likely to Receive Lifestyle Advice

February 25, 2015 7:00 am | by Univ. of Illinois | News | Comments

The American Diabetes Association recommends that health care providers counsel all patients with diabetes or at high risk of diabetes about physical activity and healthy dietary choices. But, more than half of patients with symptoms of mental illness– and nearly one-third of those who also had diabetes– said their health care providers had never told them to exercise or reduce their intake of dietary fat.

Mapping Lizard Venom Key to New Drugs

February 25, 2015 7:00 am | by Aarhus Univ. | News | Comments

The most well-known venomous lizard is the gila monster– a heavy-bodied lizard. Now, researchers have made a comprehensive description of the proteins in the venom. This knowledge not only provides insight into the function and evolution of venom proteins, but can also prove to be relevant in connection with developing new types of drugs.  

New Polio Vaccine Gets Funding for Development, Trail

February 25, 2015 7:00 am | by Georgia Institute of Technology | News | Comments

A research team has been awarded $2.5 million in grants from the Bill & Melinda Gates Foundation to advance the development of dissolvable microneedle patches for polio immunization. The patches will be studied to evaluate their potential role as part of the worldwide efforts to eradicate polio.

Merck Grants Free License on HIV Drug

February 24, 2015 3:00 pm | by Associated Press, Linda Johnson | News | Comments

Drugmaker Merck & Co. has granted a free license allowing one of its HIV medicines to be made and sold inexpensively for use in young children in poor countries hard hit by the AIDS virus. The deal, announced today, lets any generic or brand name drug manufacturer make low-cost pediatric versions of Merck's raltegravir for sale in 92 low- and middle-income countries.

Molecule Links Obesity, Type 2 Diabetes

February 24, 2015 7:00 am | by UC San Diego | News | Comments

Obesity causes inflammation, which can, in turn, lead to type 2 diabetes. Now, researchers have discovered that the inflammatory molecule LTB4 promotes insulin resistance, a first step in developing type 2 diabetes. What’s more, they found that genetically removing the cell receptor that responds to LTB4, or blocking it with a drug, improves insulin sensitivity in obese mice.

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Fearing Ebola, N. Korea Bans Foreigners from Marathon

February 23, 2015 8:20 am | by Associated Press, Eric Talmadge | News | Comments

Further restricting travel to the already isolated country, North Korea barred foreigners from one of its most popular tourist events— the annual Pyongyang marathon— because of concerns over the Ebola virus, travel agencies said today.

FDA Makes DNA Screening for Diseases More Accessible

February 20, 2015 3:00 pm | by Associated Press, Matthew Perrone | News | Comments

Federal health officials are easing access to DNA tests used to screen parents for devastating genetic disorders that can be passed on to their children. The surprise announcement offers a path forward for Google-backed genetic testing firm 23andMe, which previously clashed with regulators over its direct-to-consumer technology.  

Superbug at UCLA Kills Two, 179 Exposed

February 19, 2015 3:00 pm | by Associated Press, Robert Jablon | News | Comments

Contaminated medical instruments are to blame for infecting seven patients, including two who died, with a potentially deadly "superbug" at a Los Angeles hospital, officials said. A total of 179 patients have been exposed to the antibiotic-resistant bacteria.  

Engineered Bone Marrow Yields Platelets

February 19, 2015 7:00 am | by Tufts Univ. | News | Comments

A team has reported development of the first 3-D tissue system that reproduces the complex structure and physiology of human bone marrow and successfully generates functional human platelets. Using a biomaterial matrix of porous silk, the new system is capable of producing platelets for future clinical use and also provides a laboratory tissue system to advance study of blood platelet diseases.  

Giant Bacteria May Have Uses in Nanoscale Industry

February 19, 2015 7:00 am | by American Society for Microbiology | News | Comments

Scientists have grown E. coli that stretch three quarters of a millimeter. That's up to 750 times their normal length. The research has potential applications in nanoscale industry, and may lead to a better understanding of how pathogens work.

State Considers Trimming Vaccine Exemptions

February 18, 2015 8:12 am | by Associated Press, Rachel La Corte | News | Comments

Personal or philosophical opposition to vaccines would not be an authorized exemption for the parents of school-age children under a measure that received a public hearing before a House committee in Washington state, drawing at least two dozen opponents to the proposed change.

Drug Exposure Linked to Autism-like Behavior

February 18, 2015 7:00 am | by Brown Univ. | News | Comments

Research suggests that fetal exposure to chemicals or drugs can cause neurological problems. Babies whose mothers take the epilepsy drug valporic acid during pregnancy, for example, appear to have an elevated risk of developing an autism spectrum disorder. In a new study, scientists who developed a tadpole model of this exposure directly observed deleterious effects on brain physiology and behavior.

Self-regulation of Pharma Industry Fails

February 18, 2015 7:00 am | by PLOS | News | Comments

A discrepancy exists between the ethical standard codified in the pharmaceutical industry Codes of Practice and the actual conduct of the pharmaceutical industry, at least in the UK and Sweden.

Algorithms Spot Effective Pain Drugs

February 18, 2015 7:00 am | by Univ. of Oxford | News | Comments

More than 90 percent of central nervous system drugs fail when they're tried in large human trials. But, computer algorithms can tell apart the drugs that provide effective pain relief from ineffective placebos.

AIDS is the No. 1 Killer of African Adolescents

February 17, 2015 3:00 pm | by Associated Press, Tom Odula | News | Comments

AIDS has become the leading cause of death for adolescents in Africa and the second leading cause of death among adolescents globally, global health agencies said today. About 120,000 people aged between 10 and 19 years died of AIDS-related illnesses in 2013.  

'Glue' Find Sheds Light on Sudden Cardiac Death

February 17, 2015 3:00 pm | by Oxford Univ. | News | Comments

A protein has been shown to have a surprising role in regulating the “glue” that holds heart cells together. This discovery could explain how a gene defect may cause sudden cardiac death.

Tech Key to Novel Synthetic Polio Vaccine

February 16, 2015 3:00 pm | by Diamond Light Source | News | Comments

Scientists are using technology that helped in the design of a new synthetic vaccine to combat the foot and mouth disease virus to target the virus that causes polio. The synthetic vaccine would provide a powerful weapon in the fight to rid the world of polio.

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