Gilson’s Fraction Trapping Liquid Chromatography (FTLC) System removes 95 percent of water content in fractions, thus decreasing dry-down time. The system incorporates the durability of the GX-271 liquid handler/injector, the power of three 306 HPLC pumps and the precision of the 155 UV/VIS detector with the ability for column switching via the VALVEMATE II valve actuator. The FTLC system is suited for processing fractions up to 25 mL volume and sample masses up to 500 mg that have been purified on virtually any preparative HPLC system. The collected fractions are re-processed on the FTLC system. The compounds are trapped on a polymer-based column and the water content of the fractions passes through to waste. Additionally, washing steps can also be performed for removal of salts, buffers and mobile phase modifiers such as TFA that can hinder further LC/MS analysis. Fractions containing >50% water content can be processed and collected in 100 percent of organic solvent. This allows for fast dry-down times at lower temperatures for samples that are heat-sensitive. Dry-down times of 12 to 24 hours can be reduced to <30 min.
Michelle LongoAsst. Managing Editor
Slow and Steady Wins the RaceIn the 100 years since Marie Curie won the Nobel Prize in Chemistry, women have made leaps and bounds in science and engineering. Following the extreme example of Madame Curie, women have exponentially raised their position in S&E in the last few decades. In a field previously (and traditionally) dominated by men, women seem to be slowly but surely taking over—or at least leveling the playing field. ...continue