High-Res System Streamlines ADME Assays

The RF360 High Resolution System from BIOCIUS Life Sciences and Agilent Technologies is suited for high‐throughput screening of in vitro ADME assays. Combining the accurate mass capabilities of Agilent’s time‐of‐flight (TOF) mass spectrometers and the sample processing speed of RapidFire technology, the instrument improves in vitro ADME analysis by eliminating the method development bottleneck in drug discovery. High-resolution mass spectrometry coupled with the sample preparation throughput of the RapidFire platform enables significant streamlining of in vitro ADME assays, and the approach reduces analysis time to a fraction of that of conventional methods while requiring a minimal amount of operator input. 

RapidFire technology combined with TOF mass spectrometers enables a wide range of ADME assays, including drug‐drug interaction, metabolic stability, Caco‐2, PAMPA and others. When performing such assays with the RF360, a priori knowledge of the test compound is not required, as data is acquired in full scan TOF‐MS mode. Post acquisition, the relevant data is extracted using RapidFire software, eliminating the time consuming and labor intensive steps of LC-MS method development and batch analysis.

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