Redesigned Centerpiece Enhances Ultracentrifuge Performance  Redesigned centerpieces used in the Beckman Coulter XL-A and XL-I analytical ultracentrifuges allow the systems to provide precise, repeatable measurement of sample aggregation in pharmaceutical research and formulation labs.
Enhancements to the carbon epon (epoxy) and aluminum epon centerpieces improve the systems’ protein aggregation measuring capability, increasing precision and accuracy from test to test.
The ultracentrifuges are suited for drug discovery and vaccine development processes by characterizing a protein’s behavior in free solution under physiological concentrations, temperatures and buffer conditions. Their operating systems do not require calibration or the use of standards, allowing measurements of proteins and other macromolecules to be characterized as interacting, not isolated, elements. Simple yes/no answer capability function provides quick answers to questions regarding aggregation, interacting/self-associating systems, stoichiometry and molecular conformation.
The XL-A, with absorbance optics, provides the selectivity and sensitivity to measure protein behavior at wavelengths between 190 to 800 nm. The XL-I adds Rayleigh interference optics, which allow the use of UV-absorbing buffers and provide the ability to study highly concentrated samples.
The carbon epon centerpiece is chemically inert and compatible with a variety of proteins and macromolecules. The aluminum epon centerpiece is offered as an alternative for low-concentration solutions because it will not bind samples.
Both units can be used at speeds up to 60,000 rpm and feature a long, two-channel path-length that enables more data points to be collected before samples pellet.
Beckman Coulter, Inc.
90 Boroline Road
Allendale NJ 07401
Phone: 201-818-8900
Fax: 201-818-9740
http://www.beckmancoulterlims.com
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