Thermo Fisher Scientific Hypersil GOLD HILIC columns, available with 1.9-, 3- and 5-µm particle sizes, are suited for applications within drug discovery, food testing and environmental analysis. Hydrophilic interaction liquid chromatography (HILIC) is becoming an increasingly popular technique that offers complementary selectivity to reversed-phase. With the ability to retain highly polar and hydrophilic compounds, this HILIC range of columns has been developed to aid the analysis of compounds that are traditionally difficult to retain using conventional C18 columns. HILIC works by incorporating water in the highly organic mobile phase to form, an adsorbed water-rich layer on the polar stationary phase surface into which analyte molecules partition. Retention is governed by dipole-dipole interactions and hydrogen bonding mechanisms. Furthermore, the highly organic mobile phase contains low salt levels, making the columns suitable for use with electrospray mass spectroscopy.
Michelle LongoAsst. Managing Editor
Slow and Steady Wins the RaceIn the 100 years since Marie Curie won the Nobel Prize in Chemistry, women have made leaps and bounds in science and engineering. Following the extreme example of Madame Curie, women have exponentially raised their position in S&E in the last few decades. In a field previously (and traditionally) dominated by men, women seem to be slowly but surely taking over—or at least leveling the playing field. ...continue