Supercomputers Design Super-Charged Antioxidants
The future of keeping aging-related diseases at bay lies with the supercomputer according to scientists from the ARC Centre of Excellence for Free Radical Chemistry and Biotechnology at the Univ. of Sydney.
The research, led by Prof. Leo Radom from the university's School of Chemistry, and Amir Karton, Univ. of Western Australia, has used sophisticated quantum chemistry and powerful supercomputers to design improved antioxidants that will help stave off aging-related diseases such as heart disease, cancer, diabetes and Alzheimer's disease.
"While most people consume wine, berries and chocolate for an antioxidant boost, we turned on our computers. We were able to use supercomputers to improve the power of natural antioxidants and this may provide future benefit to the health industry," says Karton.
Antioxidants work by scavenging free radicals and other oxidative species, preventing them from causing damage to the body's tissues and organs. In this research the team, working alongside Prof. Michael Davies and David Pattison from the Heart Research Institute, studied a particular type of antioxidant found in meat, fish and eggs called carnosine, and investigated its effectiveness in scavenging the oxidant, hypochlorous acid.
Hypochlorous acid can be of benefit to the body when it is used as part of our immune system to fight off invading pathogens. However, excessive levels of hypochlorous acid in the wrong place or at the wrong time have been linked to the development of heart disease.
"The supercomputer modeling allows us to probe deeply into the molecular structure and helps us to understand just why carnosine is such an effective antioxidant. Armed with this understanding, we are then able to design even better antioxidants," says Radom.
The findings of this research have led to a number of recommendations on how to improve the antioxidant capacity of particular molecules, and ultimately how to custom design antioxidants for specific purposes in the fight against aging-related diseases.
"Although we can't yet claim to have uncovered the fountain of eternal youth, our findings are one more step towards better treatments for aging-related disease, which we hope will improve longevity and the quality of life in the future," says Karton.