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Chrom Notebook

Bradley Schmidt
e-EditorWhen Evidence Suggests Otherwise
What if I told you that most of the antibiotics you were taking were no better than a placebo, and that my statement was based on peer-reviewed medical research? The next time you went to the doctor for an illness, would you still ask him to treat you with those same medicines? continue...

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CycloGraph Centrifugal Chromatography Device

Determination of dn/dc by Multi-Point RI Method

Enhanced Detection of Semi-Volatile Compounds using Sub-Ambient ELSD

Fast Separation of FFA, FAME, and Glycerol for Biodiesel Analysis by Supercritical Fluid Chromatography

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Articles

Massive Accomplishment
by Yingying Huang
High resolution, accurate mass LC-MS/MS technology combines with mass defect filtering software to improve the speed and efficiency of early-stage drug discovery and late-stage drug development. continue...

CO2 Saves the Green
Centrifugal fraction collection and simultaneous drying for SFC
by Michael A. Burns
Researchers and scientists understand the inherernt advantages — speed and environmental impact — of purifying small drug-like molecules with supercritical fluid chromatography such as speed and environmental impact. SFC also utilizes carbon dioxide which allows for a much wider optimal flow rate range compared to that of the liquids used in HPLC. continue...

How to Validate
Experts weigh in on the right approach to validate a liquid chromatography method
by Angelo DePalma
With instrumentation becoming easier to use, method development and validation are two of the few remaining "expert realms" in liquid chromatography. Robust methods demand a balance between speed and resolution. continue...

Products

Specialty Gas Reference Guide
The multi-edition Specialty Gases and Equipment Reference Guide from Airgas, Inc. is now available in CD and Internet formats, allowing for up-to-the-minute, automatic updates from computer desktops. continue...

Customized Automation Extends Options for Labs

As the result of a co-marketing agreement, customized integrated analytical systems with advanced front-end automation and the capability to address the higher sensitivities and specificities of current chromatography systems are available to Chromatography and Mass Spectroscopy laboratory customers for purchase, rent or lease.

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Mixed-Mode SPE-Phase for Basic Analytes

The polymer-based, strong cation exchanger, CHROMABOND HR-XC, with advanced reversed-phase properties, is suited for enriching basic compounds. This new material for solid phase extraction offers an optimized pore structure and high specific surface, achieving good reproducibility, as well as reliable and cost-efficient analysis.

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Ultra-High Resolution TOF Mass Spectrometer

The maXis mass spectrometer delivers the combination of mass accuracy better than 1 ppm, mass resolving power up to 60,000, dynamic range over 5 orders of magnitude, and 1.5 mDa high-resolution extracted ion chromatograms.

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New! 2009 Lab Trends Report
and Forecast Outlook, featuring
Corporate/Product Profiles

View the 2008 Lab Trends Report.

Videos

• Bal Seal Video Shows Dynamic Animation Sequence
•  Class II, Type B2 Biological Safety Cabinets
•   Hach's TNTplus Chemistries
•   Sealing and Conducting Solutions for Lab Automation and Analytical Equipment

• Mass Spectrometer Accelerates Proteomics Research

• Major R&D Milestone for Harnessing Ocean Energy

Multimedia

Removing Roadblocks to Chromatographic Method Development and Validation
Are trial-and-error practices slowing down your chromatographic methods development process?
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Solving Computational Chemistry Challenges
As technology provides computational chemists with exponential improvements in computational capability, they are finding ways to employ the new power to investigate formerly unaddressable research problems.
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Next-Generation Sequencing: Elements for Success
This webcast addresses directions for next-generation sequencing, solutions available to provide the scalable HPC infrastructure demanded by the research, and successful implementation of next-generation sequencing in a clinical and translational research environment.
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Milking the Melamine Mess

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Methods Development

Displacement Chromatography Comes of Age

Reviving Thin Layer Chromatography

Carbon Nanotubes Detect Lung Cancer Markers in the Breath

Editorial

Gel Permeation Chromatography