Spicing Up the Diabetes Cure

Profiling and characterization of polyphenol polymers from cinnamon

Min He, Peter Wang, Ying Xiang, Ying Qi, Howard Sun and Julian Phillips

Type 2 diabetes is the most common metabolic disease worldwide. Although the prevention and control of it remains unclear, there is strong evidence that dietary factors play a role in the onset of this disease.

Previous studies have indicated

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that cinnamon may mimic insulin effects and thus may improve glucose uptake.^1,2 Considering the complex composition of cinnamon, it is important to be able to isolate and characterize the possible active components in it. A range of reports have been devoted to the studies of this topic. However, most work has been mainly focused on the studies of monomer and dimers. The study of trimer or even larger compounds using an on-line LC-MSⁿ approach has not been reported.

The fast cycle time and high MSⁿ sensitivity of the LCQ Fleet ion trap mass spectrometer provide enhanced analytical throughput for complex natural product analysis. In this article, profiling and structural elucidation of polyphenol polymers, the possible active compounds in cinnamon, are carried out using an LC-MSⁿ methodology and the ion trap mass spectrometer. The application of pulsed-Q dissociation (PQD) and high-resolution isolation (HRI) facilitates the analysis of this complex sample.

Due to the graphs in this article a PDF has been made available for download.

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Thermo Scientific
5225 Verona Road
Madison WI 53711
Phone: 408-965-6000
Fax: 408-965-6113
http://www.thermo.com/MS

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