Alternate Selectivity for Bases in UPLC using a Non-Endcapped Silica Stationary Phase

by Jane Xu, Kenneth J. Fountain, Eric S. Grumbach, and Diane M. Diehl, Waters Corporation, Milford, MA, USA

A non-endcapped C18 stationary phase bonded to a 1.8 μm high strength silica (HSS) particle substrate was developed to provide different selectivities in UltraPerformance Liquid Chromatography (UPLC® technology) separations. ACQUITY UPLC® HSS C18 SB (Selectivity for Bases) columns provide alternate selectivity for bases under acidic conditions, and provide an additional UPLC method development tool.

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