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MS-Based Systems for Quantitative Multiplex Biomarker Verification

The MIDAS TRAQ mass spectrometry-based systems are designed to provide rapid, multiplex solutions for protein biomarker verification and validation. The high-throughput systems employ the MIDAS workflow to help researchers move from protein biomarker discovery to validation more quickly. They integrate the quantitative and qualitative capabilities of the 4000 Q TRAP and 3200 Q TRAP LC/MS/MS systems with the new Tempo nano MDLC system and automation software to provide a solution to the bottleneck between protein biomarker discovery and high-sensitivity quantitative validation. The MIDAS workflow (MRM-initiated Detection and Sequencing) can go directly from genomic or proteomic biomarker prediction, profiling, or discovery experiments to assays for biomarker verification and validation. The workflow overcomes the need for separate methods development, including the synthesis of a labeled peptide standard, for each potential biomarker.
Applied Biosystems
850 Lincoln Centre Dr.
Foster City, CA, 94404