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PTM Detection on High-Capacity Ion Trap System

A PTMscan on the proprietary PTM Discovery System can now detect PTMs by first screening for specific neutral losses during collision-induced dissociation (CID) and then triggering automatic, data-dependent ETD experiments on the fly. An important PTMscan called PhosphoScan enables the automated detection and localization of phosphorylations of peptides and small proteins. The system incorporates electron transfer dissociation (ETD) in the proprietary HCTultra ion trap mass spectrometer. ETD fragmentation breaks the peptide backbone non-ergodically and preserves functionally important post-translational modifications (PTMs), such as phosphorylation and glycosylation.
Bruker Daltonics Inc.
Manning Park
Billerica, MA, 01821