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Fluorescence Detection Capability Adds to Analytical Ultracentrifuges

Aviv Biomedical, Inc. will now sell and install its fluorescence detection system on fielded Beckman Coulter ProteomeLab XL-A, XL-I analytical ultracentrifuges. The ProteomeLab XL-A, XL-I provides analysis of heterogeneity, stoichiometry, interacting/self-associating systems and molecular conformation. It measures proteins and other macromolecules as interacting elements in solution, rather than in isolation, diluted or bound to a substrate. The Aviv analytical ultracentrifuge fluorescence detection system (AU-FDS) offers a complementary approach to measuring molecular interaction and aggregation behavior. The fluorescent labeling of a single component in a mixture enables users to validate drug lead efficacy by confirming it only binds to the desired substrate and not to other components. With the AU-FDS accessory, the XL-A, XL-I’s core absorbance/ interference detection can be run sequentially with the fluorescence optical system. In addition to rigorous characterization, the XL-A, XL-I technology measures relative changes in the distribution of molecular weights and enables the collection of many simple yes/no answers. Suited for pharmaceutical and academic research applications, the AU-FDS can be used with all Beckman Coulter rotors and centerpieces. The accessory will be sold and installed by Aviv Biomedical, and Beckman Coulter will validate the installation.
Beckman Coulter, Inc.
4300 N. Harbor Blvd., P.O. Box 3100
Fullerton, CA, 92834