Principles of Triple Detection GPC/SEC: The Deflection Refractometer (RI)

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Principles of Triple Detection GPC/SEC: The Deflection Refractometer (RI)

Max Haney, Ph.D.

Gel Permeation Chromatography (GPC), also known as Size Exclusion Chromatography (SEC), is a popular analytical tool for characterizing natural and synthetic polymers and proteins. Rapid developments in industrial, biomedical, pharmaceutical and food technologies, however, have provided a strong push to extend the capability of conventional GPC beyond relative MW measurements. In response, many users have implemented the technique of Triple Detection, which refers to the combination of concentration with viscosity and light scattering detectors, to obtain absolute MW and information on structure and conformation. This article, the first in a series of three, will explore the principles of measurement and operation of the most common concentration detector in use today, the deflection refractometer or RI...

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15600 West Hardy Road
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