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Static Headspace vs. Purge and Trap for the Analysis of OVIs and Residual Solvents
Don Harrington
Static headspace analysis and purge and trap are both sample preparation techniques for gas chromatography. In static headspace, a sample is placed in a vial that is sealed and heated. The volatile components migrate out of the sample matrix and into the headspace of the vial. A portion of the headspace is then sampled and transferred to a GC for analysis. In purge and trap analysis, a sample is placed in a vessel that is purged with an inert gas to strip out the volatile components. The volatiles are concentrated on a sorbent trap that is then rapidly heated to desorb the analytes onto a GC for analysis. Because of the concentration aspect, the technique of purge and trap extraction allows greater sensitivity over a static equilibrium process. In this paper, the two techniques are compared and could be used for USP 467 or European Pharmacopoeia (EP) compliance.
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Teledyne Tekmar
4736 Socialville Foster Rd.
Mason, OH, 45040
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