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Factors Affecting C,H,N Micro-Analytical Performance—Part 1

by Paul E. Hemming, General Manager, Exeter Analytical Ltd.


Introduction
The origin of accurate elemental analysis of milligram quantities of organic compounds can be traced back to the 1923 Nobel Prize winning work by Pregl.1,2

During the ensuing forty years, the development of new global synthetic chemical industries created an escalating demand for elemental microanalysis. As demand to analyze greater numbers of samples rose, the need to automate the micro-analytical procedures while maintaining the accuracy and precision of the classical techniques became apparent. The 1960s3 saw the introduction of the first automated elemental analyzers, which quickly gained acceptance in laboratories throughout the world. Today the requirements for high data quality, reliability, system productivity and ease of use have placed demands on analysts and instrument designers alike. Only certain micro-analytical instrument designs appear able to deliver these goals.

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