Easy to set up and use, the PLS organic synthesizer can perform up to 24 reactions simultaneously. Applications include fast lead generation, reaction optimization, accelerated process development and combinatorial catalysis. The instrument accommodates a selection of glass solution phase and Teflon solid phase reactors (1 to 50 mL). Powerful, variable-speed vortex mixing ensures the system can cope with almost any reaction medium effectively. Also, the versatile synthesizer can be adapted to operate at sub-ambient or elevated temperatures from -80 C to 150 C. Options for parallel washing and cleavage further enhance productivity. Manufactured from materials chosen for their robustness and chemical resistivity, the compact synthesizer fits in almost any fume hood and provides long-term reliability.