Chromatography Techniques

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Chrom Notebook

Stimulus Winners and Losers

Tim Studt, Editor-in-Chief
Tim Studt
Editor in Chief
According to a recent report, “Investing in Innovation for Long-Term Growth,” by the Organization for Economic Cooperation and Development (OECD), the global economic downturn has begun to affect innovation as measured by reduced industrial investment in R&D and a smaller number of recent patent filings. The June 2009 report notes, however, that the downturn can “magnify the competitive advantage of research-intense firms who seize the opportunity to reinforce market leadership through increased spending on innovation and R&D.”...continue


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CO2 Saves the Green
Centrifugal fraction collection and simultaneous drying for SFC
by Michael A. Burns
Researchers and scientists understand the inherernt advantages — speed and environmental impact — of purifying small drug-like molecules with supercritical fluid chromatography such as speed and environmental impact. SFC also utilizes carbon dioxide which allows for a much wider optimal flow rate range compared to that of the liquids used in HPLC.
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How to Validate
Experts weigh in on the right approach to validate a liquid chromatography method
by Angelo DePalma
With instrumentation becoming easier to use, method development and validation are two of the few remaining "expert realms" in liquid chromatography. Robust methods demand a balance between speed and resolution.
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Massive Accomplishment
by Yingying Huang
High resolution, accurate mass LC-MS/MS technology combines with mass defect filtering software to improve the speed and efficiency of early-stage drug discovery and late-stage drug development.
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Streamlined Systems for Gas Analysis

Shimadzu Scientific Instruments updated its existing system GC program to include the GC-2014 gas chromatograph. 

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HPLC and UHPLC in One Efficient System

The Thermo Scientific Accela high-speed chromatographic system provides fast, efficient chromatographic separations over an expansive range of flow rates and pressures. 

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Q-TOF MS Benchtop System Maximizes Data from Minimal Sample Amounts
The Xevo quadrupole time-of-flight (Q-TOF) mass spectrometer (MS), an exact mass MS-MS instrument, is an extremely sensitive benchtop system. This Q-TOF is designed around the philosophy of Engineered Simplicity, which combines instrument performance with simplicity of operation continue...

Specialty Gas Reference Guide
The multi-edition Specialty Gases and Equipment Reference Guide from Airgas, Inc. is now available in CD and Internet formats, allowing for up-to-the-minute, automatic updates from computer desktops. continue...



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Removing Roadblocks to Chromatographic Method Development and Validation
Are trial-and-error practices slowing down your chromatographic methods development process?
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Solving Computational Chemistry Challenges
As technology provides computational chemists with exponential improvements in computational capability, they are finding ways to employ the new power to investigate formerly unaddressable research problems.
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