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Pseudoephedrine Identification in Illicit Drug Mixtures using UHPLC-MS
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03/16/2009
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The diversion of over-the-counter pseudoephedrine-containing products is one of the major contributing factors in the rise of meth production and abuse worldwide. Successful separation and identification of pseudoephedrine in illicit drug mixtures can help identify the exact sources and manufacturing pathways of meth seized in the illicit drug market.
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Improving Performance in Crimping and Decapping Operations and Reducing User Strain
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02/17/2009
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Wheaton Industries newest addition, dubbed the Crimpenstein, is a hand-held tool used to crimp and decap aluminum seals on or off of bottles and vials. This unit utilizes an ergonomic design to make crimping and decapping quick and easy. The Crimpenstein comes with interchangeable heads making it versatile and economical. It can be used on standard 8, 11, 13, & 20mm aluminum seals.
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Enhance Retention of Sulfur-Containing Compounds Through π-π Interactions
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01/26/2009
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Pharmaceutical actives and impurities often contain sulfur in the form of a sulfone or sulfoxide group. Both groups have dipole moments, adding a hydrophilic character to compounds containing these functional groups. The analysis of hydrophilic compounds on traditional alkyl columns (e.g. C18) can be problematic, since alkyl columns depend on hydrophobic interactions for retention.
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Determination of Melamine in Food by Ion Chromatography (AW CN6-0013-122008)
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01/26/2009
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by Dr. Markus Läubli, Marketing Manager, Metrohm AG
The high nitrogen level in melamine - 66% nitrogen by mass - gives it the analytical characteristics of protein molecules. When added to milk, melamine increases the nitrogen concentration, which suggests a false increase in protein concentration. Melamine has low oral acute toxicity but excessive exposure in animals causes renal stones. When consumed by human beings, babies and children are affected the most because of their dependence for nutrition, compounded by immaturity of their organs, which renders them vulnerable to chemical damage.
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Caveat About Directly Replacing Acetonitrile with Methanol in HPLC Mobile Phases
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01/26/2009
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by William Campbell, Research Development Manager, Sigma-Aldrich/Supelco
Any practicing chromatographer knows the importance of acetonitrile as a mobile phase component for reversed-phase separations. With the uncertain supply of acetonitrile, and other reasons, many laboratories have replaced it, or are looking into replacing it with methanol. There is a general rule of thumb to increase the organic component by ten percentage units when changing from acetonitrile to methanol in a reversed-phase method.
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Rapid Analysis of 5 aminolevulinic Acid
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01/26/2009
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by Jean-Philippe Veyssier, Biochrom Ltd.
5-aminolevulinic acid (ALA) is an early precursor in the synthesis of the heme, which is involved in the composition of haemoglobin, and is synthesized in the mitochondrion. 5-aminolevulinate dehydrogenase deficiency leads to accumulation of ALA. The principal problem in this deficiency is the accumulation of porphyrins and their chemical precursors (such as ALA), which are toxic to tissue in high concentrations.
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Analysis of Melamine and Cyanuric Acid in Infant Formula
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01/26/2009
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by Jeremy Shia and Diane Diehl, Waters Corporation
Responding to recent worldwide concern related to melamine in food, the US FDA issued an interim method for the determination of residual melamine and cyanuric acid in foods using LC–MS–MS. Based upon that work, this application note describes the rapid, specific analysis of melamine and cyanuric acid in infant formula by UPLC–MS–MS.
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Analysis of Theanine Using the Biochrom 30
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01/06/2009
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by Jean-Philippe Veyssier, Biochrom Ltd.
The Biochrom 30 Amino Acid Analyser is a well established analytical instrument for clinical diagnosis as its IVD approval allows the diagnosis of inborn errors of metabolism such as Phenylketonuria. The Biochrom 30 can also be used for analysing rare, unusual amino acids or derived molecules for research purposes. In order to develop new methods for analysing molecules of interest in the scientific market, a new application has been developed to analyse the theanine content in green tea leaves.
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DPX for Drugs of Abuse
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12/18/2008
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Disposable Pipette Extraction is a fast and efficient SPE technique used for a wide range of applications such as drugs of abuse and therapeutic drug monitoring. Only 200-250 μL of sample is needed to reach the required limits of detection using a fully automated process. The extraction step is performed in 30-60 seconds, the complete process including elution, etc., in 3-6 minutes depending on the application.
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